2014 Fiscal Year Final Research Report
Occurrence of fibrates and their metabolites in aquatic environments in China and their effects on aquatic organisms
| Project/Area Number |
24406008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tsuyoshi 岐阜薬科大学, 薬学部, 准教授 (50303988)
IDO Akiko 岐阜薬科大学, 薬学部, 助手 (00336629)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROMORI Youhei 金城学院大学, 薬学部, 助教 (60515956)
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| Research Collaborator |
YANG Min
HU Jianying
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 水環境 / フィブラート / PPCPs / PPAR |
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| Outline of Final Research Achievements |
Fibrates, which are widely used as lipidemic-modulating drugs, are poorly removed during typical drinking water treatment, and thus may remain in drinking water after treatment of source water. In this study, we established liquid chromatography-electrospray tandem mass spectrometry combined with weak anion exchange solid-phase extraction to simultaneously determine trace levels of 3 typical fibrates and 2 of their metabolites in source water and finished water samples collected from 10 drinking water treatment plants in China. In source water, all target compounds were detected at ng/L concentrations and all compounds except fenofibrate were detected in finished water. The peroxisome proliferator-activated receptor α (PPARα) agonistic activities of all target compounds were detected at mg/L concentrations by a PPARα reporter assay; therefore, the present results suggest that the fibrate concentrations in drinking water in China have no significant effect on human health.
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| Free Research Field |
毒性学
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