Studies on an ultraviolet-absorbing photopigment, Opsin 5 in vertebrate eye and brain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500382
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Okayama University
• Principal Investigator: OHUCHI Hideyo 岡山大学, 医歯(薬)学総合研究科, 教授 (00253229)
• Co-Investigator(Renkei-kenkyūsha): BANDO Tetsuya 岡山大学, 大学院医歯薬学総合研究科, 助教 (60423422) ; FUJITA Hirofumi 岡山大学, 大学院医歯薬学総合研究科, 助教 (20423288) ; YASUE Akihiro 徳島大学, 大学院HBS研究部, 講師 (80380046)
• Research Collaborator: INOUE Junji ; KATO Mutsuko
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: オプシン５ / Opsin 5 / Opn5 / 光 / 紫外光 / 眼 / 脳 / 視床下部

Outline of Final Research Achievements

This research project was aimed for clarifying the functions for an ultraviolet-absorbing photopigment, Opsin 5 in vertebrates such as mouse and chicken by use of a genome-editing technique, TALEN (Transcription activator-like effector nuclease). We succeeded in production of Opn5-knockout mice by this method, finding that Opn5-deficient mice were born alive and seemed healthy at least after 3 weeks postnatal.

Free Research Field

細胞組織学、発生生物学、神経科学