Development of a minimally invasive pin-point-treatment of cancer cells utilizing active hydrogen discharged from hydrogen storage alloys

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Nagasaki University
• Principal Investigator: KAGAWA akio 長崎大学, 工学研究科, 教授 (00093401)
• Research Collaborator: YAMAMOTO Masataka 長崎大学, 工学研究科, 助教
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 水素貯蔵合金 / パラジウム / ニッケル / 鉄 / 癌細胞 / 正常細胞

Outline of Final Research Achievements

Three subjects have been investigated in the present work.(1) effects of composition and sample shape on the death of cancer cells, (2) the mechanism of cell death and (3) evaluation of bending motion of hydrogen storage alloy(HSA) micro-actuator. The optimum alloy composition is Pd-5at.%Ni and HeLa cancer cell death was observed in the region 2-3 mm apart from the HSA sample.In Pd-7at.%Fe alloy, the death of HeLa cancer cells and MDCK normal cells by anoikis was detected, while a selective cancer cell death was observed in Pd-5at.%Fe alloy specimen.The mechanism of the selective death of cancer cells is clarified on the basis of experiments using fluorescent reagents. The selective death of cancer cells is attributed to a lack of the enzyme, “catalaze” in the cancer cells. The bending motion of micro-actuator utilizing HSA is extensively modified by Pd-spattering and choosing an optimum sample shape.

Free Research Field

生体機能材料