The application to cancer vaccine of SSF that mimics pulmonary surfactant

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500527
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Musashino University (2013-2014); The University of Tokushima (2012)
• Principal Investigator: MIZUNO Dai 武蔵野大学, 薬学研究所, 講師 (70380061)
• Co-Investigator(Renkei-kenkyūsha): KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺サーファクタント / 粘膜免疫 / ワクチン / 生体機能材料

Outline of Final Research Achievements

The cellular immunity inducing effect of SSF, a synthetic adjuvant that mimics pulmonary surfactant, were shown in this study. Nasal inoculation of vaccine and SSF induced IgG2a antibody, IFN-γ secreting T cell, and cytotoxic T cell. SSF is assumed to be a mucosal adjuvant that useful for cancer vaccine therapy.

Free Research Field

医歯薬学