Effects of chronic exercise on spatial memory in rats of neonatal hypothyroidism.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500805
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Nakamura Gakuen College
• Principal Investigator: NAKANO HIROSHI 中村学園大学, 教育学部, 准教授 (60301678)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 運動 / 甲状腺ホルモン / 空間記憶 / 記憶消去 / モリス水迷路

Outline of Final Research Achievements

The purpose of this study was to clarify whether chronic exercise after the spatial memory acquisition by aversive stimulation causes extinction of the spatial memory and changes of protein expression of brain derived neurotrophic factor (BDNF) and its receptor TrkB using rats induced hypothyroidism in the neonatal period. In normal rats, the retention of the spatial memory by Morris water maze (MWM) has been reduced after chronic running exercise, and BDNF in dorsal hippocampus has increased. In hypothyroid rat, the retention of the spatial memory by MWM has been reduced after chronic running exercise, and TrkB in the dorsal hippocampus has increased. It was suggested that chronic exercise after spatial memory acquisition by aversive stimulation would cause extinction of the spatial memory, and mechanisms of the extinction of the spatial memory in hypothyroid rats would be different from that in normal rats.

Free Research Field

スポーツ生理学