New function of fat-soluble compounds for improvement of life style diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Minatogawa College (2014); Kobe University (2013); Kyoto Prefectural University of Medicine (2012)
• Principal Investigator: ADACHI Tetsuya 湊川短期大学, その他部局等, 教授 (60345014)
• Co-Investigator(Renkei-kenkyūsha): 松永 哲郎 鳴門教育大学, 講師 (10452286) ; 奥野 恭史 京都大学, 教授 (20283666)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: GPCR / 生活習慣病

Outline of Final Research Achievements

We examined the expression and function of G-protein coupled receptor (GPCR) for fat-soluble compounds in circulation and skeletal muscle system. We discovered the expression of some fat-soluble ligand receptors in heart and skeletal muscle. GPR30 is the GPCR for estrogen. Estrogen induced the phosphorylation of ERK signal cascade in primary-cultured cardiomyocyte and skeletal muscle cell line. Moreover, estrogen via GPR30 induced the proliferation and the highly-expression of several transcription factors of these cells. These results suggest that new function of G-protein coupled receptor (GPCR) for fat-soluble compounds improves for life style diseases and metabolic syndrome.

Free Research Field

病態生理学