Development of zebrafish-based assay to detect developmental neurotoxicity of irradiation and to identify protectants against the neurotoxicity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24510069
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Mie University
• Principal Investigator: NISHIMURA Yuhei 三重大学, 医学(系)研究科(研究院), 准教授 (30303720)
• Co-Investigator(Kenkyū-buntansha): TANAKA Toshio 三重大学, 大学院医学系研究科, 教授 (00135443) ; SHIMADA Yasuhito 三重大学, 大学院医学系研究科, 助教 (40378427) ; UMEMOTO Noriko 三重大学, 大学院医学系研究科, 助教 (40649365)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線 / 発達神経毒性 / 行動解析 / 治療薬 / スクリーニング / ゼブラフィッシュ

Outline of Final Research Achievements

The developing brain is extremely sensitive to irradiation. Irradiation during development has been implicated in various neuropsychiatric and neurological disorders. In this study, we were able to develop zebrafish-based behavior assay to detect subtle but significant developmental neurotoxicity of irradiation and to identify chemicals protective to the developmental neurotoxicity of irradiation.

Free Research Field

システムズ薬理学・毒性学