2014 Fiscal Year Final Research Report
Asymmetric construction of a stereogenic carbon center substituted with aryl groups
| Project/Area Number |
24550117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
EBE Yusuke
NAGAMOTO Midori
TAKECHI Ryosuke
HATANO Miyuki
YAMAUCHI Daisuke
NAGAI Tomotaka
FUJIMOTO Hiroto
NOISHIKI Akira
TAKIGUCHI Yuka
MAEDA Yuko
ASHOURI Akram
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 不斉合成 / 触媒反応 / ロジウム / アリールボロン酸 / イリジウム |
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| Outline of Final Research Achievements |
We have developed Rh-catalyzed arylation methods by use of arylboron reagents for the synthesis of chiral compounds having a stereogenic carbon center that is substituted with aryl groups. The use of chiral diene ligands base on a tetrafluorobenzobarrelene (tfb) framework was found to be effective in catalyzing the arylation reaction with high enantioselectivity. It was also found that Ir-catalyzed annulation of aromatic imines with 1,3-dienes or alkynes proceeds via C-H bond activation with high stereoselectivity.
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| Free Research Field |
有機化学
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