Molecular mechanism of the non-uniform response and reversible differentiation of stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590232
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Hiroshima University (2013-2014); The University of Tokyo (2012)
• Principal Investigator: TAKAHASHI SHUJI 広島大学, 理学(系)研究科(研究院), 特任准教授 (90447318)
• Co-Investigator(Kenkyū-buntansha): ARIIZUMI Takashi 玉川大学, 農学部, 教授 (30286166) ; TANAKA Toshiaki 東京工業大学, 生命理工学研究科, 助教 (40263446) ; NINOMIYA Hiromasa 東京大学, 総合文化研究科, 学術研究員 (40514237)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アフリカツメガエル / ネッタイツメガエル / ヒトiPS細胞 / 細胞分化

Outline of Final Research Achievements

In this study, we screened switch factors for two different endoderm in Xenopus. Using information from DNA array and study of the other model animals, a lot of gene are cloned and tested by overexpression.
However, the factors did not identified. We are trying to functional screening.
We developed a new induction method from human iPS cell to embryonic endoderm. Using this methods, We are trying to induce pancreatic endoderm.

Free Research Field

発生生物学、幹細胞