A novel approach in the treatment of metastatic gastric cancer: targeting the STn synthase

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: SATO Yasushi 札幌医科大学, 医学部, 講師 (80343383)
• Co-Investigator(Kenkyū-buntansha): TAKIMOTO Risyu 札幌医科大学, 医学部, 准教授 (10336399) ; KATO Jyunji 札幌医科大学, 医学部, 教授 (20244345) ; HIRAKAWA Masahiro 札幌医科大学, 医学部, 助教 (50561023)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 胃癌 / 転移

Outline of Final Research Achievements

ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis. However, the functional contribution of ST6GalNAc I to development or progression of gastric cancer remains unclear. We investigated the effects of suppression of ST6GalNAc I on gastric cancer in vitro and in vivo. ST6GalNAc I siRNA inhibited gastric cancer cell growth, migration, and invasion in vitro. Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer. Therefore, ST6GalNAc I may be a potential target for treatment of metastasizing gastric cancer.

Free Research Field

消化器病