A study on biomarker of dementia of Lewy bodies with dopamine transporter imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591733
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: UEDA Satoshi 日本医科大学, 医学部, 講師 (80465294)
• Co-Investigator(Kenkyū-buntansha): OKUBO Yoshiro 日本医科大学, 医学(系)研究科, 教授 (20213663) ; TATENO Amane 日本医科大学, 医学部, 准教授 (50297917)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: DLB / DAT imaging / dopamine transportaer

Outline of Final Research Achievements

It does not appear easy to correctly diagnose patients with dementia with Lewy bodies (DLB). Although there is no definite diagnostic biomarkers for DLB, dopamine transporter (DAT) imaging using PET is considered possibly usuful as one of the strong biomarkers.
DAT imaging was conducted for patients with depression or parkinsonism, which DLB often accompanies. DAT imaging made it very easy to diagnose DLB among depressive or parkinsonic patients. These findings suggest that DAT imaging using PET may be a clinically useful biomarker for DLB.

Free Research Field

geriatric psychiatry