Investigation for early epileptogenetic features of human cortical tissues

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Niigata University
• Principal Investigator: OISHI Makoto 新潟大学, 脳研究所, 非常勤講師 (00422593)
• Co-Investigator(Renkei-kenkyūsha): HIRAISHI Tetsuya 新潟大学, 医歯学総合病院, 医員 (80515734) ; KITAURA Hiroki 新潟大学, 脳研究所, 助教 (80401769)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: てんかん原性 / 神経生理 / 大脳皮質 / 神経ネットワーク

Outline of Final Research Achievements

To characterize the physiological condition of human epileptic neocortex, we employed flavoprotein fluorescence imaging (FFI) and immunohistologically studied human cortical specimens. We found that correlations between specific FFI findings and decreases in parvalbumin positive neurons may represent an imbalance between excitatory and inhibitory systems in the epileptic neocortex.We believed that the characteristics of human cortical tissues in the early epileptogenetic stage have been visualized by this study.

Free Research Field

てんかん