2014 Fiscal Year Final Research Report
Effect of micro-RNA on tachyarrhythmia in septic condition.
| Project/Area Number |
24592362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 敗血症 / 頻脈性不整脈 |
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| Outline of Final Research Achievements |
Effect of micro-RNA on channel remodeling in atrial cardiac myocyte on atrial fibrillation in septic condition was investigated. Septic condition was induced by the injection of lipopolysaccharide, and in this model, expression of L-type calcium channel was inhibited, but expression of delayed rectified potassium channel was enhanced. At the same time, expression of inducible nitric oxide was enhanced. In the blood, micro particles that contain micro RNA were observed, but direct relationship between micro-RNA and channel remodeling could not find. It was suspected that channel remodeling in septic condition might be a direct effect of inflammatory cytokines.
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| Free Research Field |
麻酔科学，薬理学
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