2015 Fiscal Year Final Research Report
The screening of the inhibitory factor for neovascularization in lens and the establishment of new concept for the pathology of neovascular glaucoma
| Project/Area Number |
24592620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INATANI Masaru 福井大学, 医学部, 教授 (40335245)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 血管新生 / 水晶体 / クリスタリン / 糖尿病網膜症 |
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| Outline of Final Research Achievements |
The result of western blotting and real time PCR indicates that α-crystallins may be derive from not only hyalocyte but leak or secretion from lens. Our study showed inhibitory effect of αB-crystalline on cell proliferation statistically and the effect were intensified with αA-crystalline in a synergistic manner. The disruption of homeostasis in eyes subsequent to lens removal causes the lower expression of α-crytallins and imbalance of crystalline and VEGF may induce the formation of abnormal capillary to vitreous cavity.
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| Free Research Field |
眼科
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