2014 Fiscal Year Final Research Report
Proposal of a disease model by optogenetics
| Project/Area Number |
24659221
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
|
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| Research Institution | Hokkaido University (2014)
Osaka University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 神経活性化 / 炎症回路 / 炎症反応 |
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| Outline of Final Research Achievements |
We have stimulated nerves in sympathetic ganglia around the fifth lumbar cord by using light stimulation in Thy1 channel rhodopsin transgenic mice. This stimulation induced the increment of chemokine expression in dorsal vessels in the fifth lumbar cord. Furthermore, an intensity of chemokine expression was correlated with intensity and times of light stimulations. And we could induce the development of EAE by using light stimulations for sympathetic ganglia in MOG reactive T cell transferred mice. This result indicated that regional neural activation could induce the development of EAE and put forward a new model to analysis of autoimmune diseases including multiple sclerosis.
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| Free Research Field |
免疫学
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