2014 Fiscal Year Final Research Report
Weather changes and Migraine attacks: relationship, mechanism and strategy
| Project/Area Number |
24659292
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 片頭痛 / 三叉神経節 / CSD / 気象病 / 頭痛 / 気圧変化 |
|---|
| Outline of Final Research Achievements |
Migraineurs frequently report that their attacks may be precipitated by “triggers.” Many migraineurs thought that weather and barometric changes triggered their migraine attacks. We evaluated relationship between barometric change and clinical records of headache attacks. Results of our study suggest that barometric changes may contribute to onset of migraine attacks.
In this study, we investigated the response in the dura mater to nociceptive stimulation. We also examined the level of ERK phosphorylation in the trigeminal ganglion following cortical spreading depression (CSD), which is thought to play an important role in migraine pathophysiology. These results indicate that CSD can activate dural TRPV1 to send nociceptive signals to the trigeminal system, and they provide important clues regarding the relationship between CSD and the trigeminovascular system.
|
| Free Research Field |
神経内科、頭痛、認知症
|
