Biomarker discovery with wide targeted lipidomic profiling for early detection of colorectal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University (2013-2014); Kobe University (2012)
• Principal Investigator: IZUMI Yoshihiro 大阪大学, 工学(系)研究科(研究院), 助教 (70622166)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メタボロミクス / リピドミクス / 大腸がん / バイオマーカー探索 / 慢性炎症 / メタボローム解析 / 脂質

Outline of Final Research Achievements

To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer. Lipids are fundamental constituents that structurally and chemically regulate cell membranes, store energy, and can become precursors to bioactive metabolites. We developed the comprehensive lipids profiling methodology and performed serum lipidomic analysis using liquid chromatography/tandem mass spectrometry (LC/MSMS). Wide targeted lpidomic profiling was not only provide insights into the specific roles of molecular species for enteritis and colorectal cancer, but also assist in identifying potential biomarkers for colorectal cancer.

Free Research Field

メタボロミクス