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2013 Fiscal Year Final Research Report

Analysis of the maintenance of stemness of glioma initiating cells

Research Project

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Project/Area Number 24700966
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionThe University of Tokyo

Principal Investigator

KOMURO AKIYOSHI  東京大学, 医学(系)研究科(研究院), 特任研究員 (50512274)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords癌幹細胞 / 脳腫瘍 / TGF-βファミリーシグナル / BMP
Research Abstract

To investigate the effect of TGF-beta family signaling on the stemness of glioma initiating-cells (GICs), we observed that Bone morphogenetic protein 4 (BMP4) had inhibitory effects of the maintenance of stemness of GICs. And we identified novel BMP4 signal target genes in GICs by using gene expression microarray analysis and RNA-seq. Using overexpression or knockdown of these novel BMP4 target genes, we found that these genes were correlated with differentiation and infiltration of GICs. Target therapy of BMP4 signaling target genes may provide a novel strategy for glioma patients.

  • Research Products

    (8 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (1 results)

  • [Journal Article] TGF-b-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD202013

    • Author(s)
      Kimihiro C. Kawabata, Shogo Ehata, Akiyoshi Komuro, Kengo Takeuchi and Kohei Miyazono
    • Journal Title

      Oncogne

      Volume: 32 (16) Pages: 2096-2106

    • Peer Reviewed
  • [Presentation] BMP4 suppresses tumorigenic activity of glioma-initiating cells through loss of stemness properties2013

    • Author(s)
      Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Yasushi Ino, Tomoki Todo, Nobuhito Saito, Tetsuro Watabe, Caname Iwata, Daizo Koinuma, Kohei Miyazono
    • Organizer
      TGF-βファミリーシグナル国際共同研究拠点第3回国際シンポジウム
    • Place of Presentation
      愛媛
    • Year and Date
      20131028-29
  • [Presentation] BMP4 suppresses tumorigenic activity of glioma-initiating cells through loss of stemness properties2013

    • Author(s)
      Akiyoshi Komuro, Hiroaki Ikushima, Satoshi Sakai, Yasushi Ino, Tomoki Todo, Nobuhito Saito, Tetsuro Watabe, Daizo Koinuma, Kohei Miyazono
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui (USA)
    • Year and Date
      20130221-25
  • [Presentation] BMP4 suppresses tumorigenic activity of glioma-initiating cells through loss of stemness properties2013

    • Author(s)
      Akiyoshi Komuro, Satoshi Sakai, Yasushi Ino, Tomoki Todo, Nobuhito Saito, Tetsuro Watabe, Caname Iwata, Daizo Koinuma, Kohei Miyazono
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-13
  • [Presentation] Glioma Cancer Initiating Cellを標的としたTGF-βシグナル阻害剤とBMP4の併用治療効果の検討2012

    • Author(s)
      古室暁義, 生島弘彬, 江幡正悟, 渡部徹郎, 鯉沼代造, 稲生靖, 藤堂具紀, 宮園浩平
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20120627-29
  • [Presentation] BMP4 suppresses tumorigenic activity of glioma-initiating cells through loss of stemness properties2012

    • Author(s)
      Akiyoshi Komuro, Hiroaki Ikushima, Satoshi Sakai, Yasushi Ino, Tomoki Todo, Nobuhito Saito, Tetsuro Watabe, Daizo Koinuma, Kohei Miyazono
    • Organizer
      国際癌化学診療シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-12-05
  • [Presentation] 骨形成因子(BMP)4による膠芽腫腫瘍形成細胞の治療効果の検討2012

    • Author(s)
      古室暁義, 生島弘彬, 稲生靖, 藤堂具紀, 渡部徹郎, 鯉沼代造, 宮園浩平
    • Organizer
      第19回BMP研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-22
  • [Book] 治療の分子標的としてのTGF-βシグナル, 日本臨床 (70巻増刊号8, 通巻1031号)2012

    • Author(s)
      古室暁義, 宮園浩平
    • Total Pages
      256-262

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Published: 2015-06-25  

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