2013 Fiscal Year Final Research Report
Analysis of the maintenance of stemness of glioma initiating cells
| Project/Area Number |
24700966
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOMURO AKIYOSHI 東京大学, 医学(系)研究科(研究院), 特任研究員 (50512274)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 癌幹細胞 / 脳腫瘍 / TGF-βファミリーシグナル / BMP |
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| Research Abstract |
To investigate the effect of TGF-beta family signaling on the stemness of glioma initiating-cells (GICs), we observed that Bone morphogenetic protein 4 (BMP4) had inhibitory effects of the maintenance of stemness of GICs. And we identified novel BMP4 signal target genes in GICs by using gene expression microarray analysis and RNA-seq. Using overexpression or knockdown of these novel BMP4 target genes, we found that these genes were correlated with differentiation and infiltration of GICs. Target therapy of BMP4 signaling target genes may provide a novel strategy for glioma patients.
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