2014 Fiscal Year Final Research Report
fNIRS-based monitoring of the neural substrate of inhibitory control in ADHD children
| Project/Area Number |
24791083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | NIRS / ADHD |
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| Outline of Final Research Achievements |
fNIRS is a noninvasive and unrestrictive method of functional neuroimaging. Making the most of fNIRS’s merits, we have explored the neural substrate of inhibitory and attentional controls in ADHD children. Firstly, our fNIRS-based measurements successfully visualized the hypoactivation pattern in the right prefrontal and parietal cortex during an inhibition and attention task in ADHD children compared with typically developing control at a group level using fNIRS. Secondly, we clarified a method of individual classification between ADHD and typically developing control children using fNIRS with high classification accuracy with 90% sensitivity. Finally, we explored neuropharmacological effect of ADHD medications using double-blinded placebo study. Then the reduction of right prefrontaland parietal activation was normalized after taking ADHD medications, such as MPH and ATX.
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| Free Research Field |
小児発達障害
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