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2015 Fiscal Year Final Research Report

Cortisol detection system for personal stress monitoring

Research Project

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Project/Area Number 25410164
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Analytical chemistry
Research InstitutionKansai University (2015)
Kanagawa Industrial Technology Center (2013-2014)

Principal Investigator

ITO Takeshi  関西大学, システム理工学部, 准教授 (50426350)

Co-Investigator(Renkei-kenkyūsha) AOKI Nobuyoshi  神奈川県産業技術センター, 主任研究員 (10231763)
KANEKO Satoru  神奈川県産業技術センター, 主任研究員 (40426359)
SUZUKI Koji  慶應義塾大学, 理工学部, 教授 (80154540)
Citterio Daniel  慶應義塾大学, 理工学部, 教授 (00458952)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsストレス評価 / QCM
Outline of Final Research Achievements

Cortisol is well known as a stress marker of endocrine system. We focused on quartz crystal microbalance (QCM) method, which is one of label free and real time measurement of antigen-antibody interaction with simplicity, convenience and low cost. No study has been reported on cortisol detection using the QCM method. In addition, we propose a QCM sensor coupled with a passive flow system for on-site monitoring of cortisol. We optimized the condition of cortisol detection such as selecting antibody and tracer, and regeneration solution. As the results, the detection time was within 8 minutes. It took 13 minutes including regeneration step. These results indicate that out proposed cortisol detection system is convenient with highly sensitivity using passive flow system.

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Published: 2017-05-10  

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