Detailed clinicopathological characteristics and possible lymphomagenesis of type II intestinal enteropathy-associated T-cell lymphoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Fukuoka University
• Principal Investigator: Takeshita Morishige 福岡大学, 医学部, 教授 (90171636)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Shotaro 岩手医科大学, 医学部, 准教授 (10243932)
• Co-Investigator(Renkei-kenkyūsha): ISHITSUKA Kenji 鹿児島大学, 医学部, 教授 (10441742)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: enteropathy / T-cell lymphoma / C-MET / C-MYC / FISH

Outline of Final Research Achievements

Twenty-six Japanese cases of type II enteropathy-associated T-cell lymphoma (EATL) were examined. Intramucosal tumor cell spread and a zone of neoplastic intraepithelial lymphocytes (IELs) neighboring the main tumors were detected in 20 (91%) and 17 (77%) of 22 cases, respectively. Outside of the IEL zone, enteropathy with reactive small IELs and villous atrophy was detected in 11 cases (50%). Lymphoma cells expressed C-MET, p-MEK1/2, C-MYC and BCL-2 in 18 (78%), 21 (91%), 11 (42%) and 19 (73%) cases, respectively. FISH revealed chromosomal loci 7q31 (C-MET) and 8q24 (C-MYC) were amplified in 11 (65%) and 12 (71%) of 17 cases, respectively. Gain of 7q31 and C-MET expression were significantly higher in type II cases than those with peripheral CD8-positive T-cell or CD56-positive NK-cell lymphoma (P<0.01). Enteropathy partly presents near the IEL zone, and C-MET-MAPK pathway and C-MYC-BCL2-mediated cell survival may play important roles in lymphomagenesis in type II EATL.

Free Research Field

血液病理学