Differential response to a selective COX-2 inhibitor between human lumbar and cervical intervertebral disc cells on innervation and disc degeneration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460728
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Tokyo Medical University
• Principal Investigator: TANAKA HIDETOSHI 東京医科大学, 医学部, 助教 (90317876)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 頚部痛 / 椎間板性腰痛 / 神経成長因子 / 細胞外基質分解酵素 / 選択的COX-2阻害剤 / プロスタグランジン

Outline of Final Research Achievements

The molecular mechanism of developing low back pain is known as disc degeneration by MMP and following nerve innervation by NGF, however that of neck pain was unknown. The effect of selective COX-2 inhibitors, which is clinically used for both low back pain and neck pain, on NGF and MMP expressions were investigated and compared the effect between human lumbar and cervical intervertebral disc (IVD) cells. IL-1-induced NGF and MMP expression were enhanced by selective COX-2 inhibitors in both lumbar and cervical IVD cells, on the other hand, these expressions were suppressed by PGE2 and other prostanoids via EP4 receptor. Our findings would be of importance when choosing drugs for the treatment of low back pain and neck pain.

Free Research Field

脊椎脊髄外科