The basic research for establishment of a new strategy for IBMIR control in islet transplantation by ADSC

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: IKEMOTO Tetsuya 徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070) ; IMURA Satoru 徳島大学, 病院, 特任教授 (90380021) ; MORINE Yuji 徳島大学, 大学院医歯薬学研究部, 講師 (60398021) ; SAITO Yu 徳島大学, 大学院医歯薬学研究部, 助教 (50548675) ; YAMADA Shinichiro 徳島大学, 病院, 特任助教 (30579884) ; IWAHASHI Shuichi 徳島大学, 大学院医歯薬学研究部, 特任助教 (30531751) ; UTSUNOMIYA Toru 徳島大学, 大学院医歯薬学研究部, 准教授 (30304801) ; KANAMOTO Mami 徳島大学, 大学院医歯薬学研究部, 助教 (10448326) ; ARAKAWA Yusuke 徳島大学, 大学院医歯薬学研究部, 助教 (00448325)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: IBMIR / ADSC / trophic effect / blood coagulation system

Outline of Final Research Achievements

This project revealed that ADSC had the trophic effect for injured islet though VEGF signaling. As in vivo study, ADSC were trapped in reticuloendothelial system, not in injured pancreas when they were administered intravenously. Mouse coagulation system analysis and porcine islet-whole blood co-culture system revealed that the effects on these systems by ADSC were very small and required large amount of ADSC even though these effects were ADSC dose-dependent manner.

Free Research Field

消化器外科