anti-inflammatory effect of remifentanil

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463135
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: Maeda Shigeru 岡山大学, 大学病院, 准教授 (50253000)
• Co-Investigator(Kenkyū-buntansha): HIGUCHI Hitoshi 岡山大学, 大学病院, 講師 (30423320) ; TOMOYASU Yumiko 岡山大学, 医歯薬学総合研究科, 助教 (40594809)
• Co-Investigator(Renkei-kenkyūsha): ANDOH Tsugunobu 富山大学, 医学薬学研究部, 准教授 (50333498)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: レミフェンタニル / 中枢神経系 / 炎症

Outline of Final Research Achievements

In a perioperative management, a control of inflammation is important. Especially, controlling the reaction is significant since the inflammatory reaction in CNS is deeply related with post-operative cognitive dysfunction. Remifentanil, an intravenous opioid used for general anesthesia, acts on mu-opioid receptor in the CNS although its anti-inflammatory effect in the CNS remains unclear. Therefore, in this study, the anti-inflammatory effect of remifentanil in the CNS was validated. Remifentanil inhibited IL-6 mRNA reaction in CNS from animal model of systemic acute inflammation. Using C6, originating from astrocyte, remifentanil suppressed a reaction of IL-6 mRNA to LPS. Remifentanil also suppressed cAMP reaction to LPS in C6 while cAMP increased the reaction of IL-6 mRNA to LPS. Thus, it is suggested that remifentanil suppressed inflammatory reaction in CNS, throught inhibits the reaction of cAMP against LPS in astrocyte, at least in part.

Free Research Field

歯科麻酔学