Development of N(5)-Unsubstituted Neutral Flavin Catalysts with High Catalytic Activity towards Oxidation Reactions

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620086
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: The University of Tokushima
• Principal Investigator: IMADA Yasushi 徳島大学, ソシオテクノサイエンス研究部, 教授 (60183191)
• Co-Investigator(Kenkyū-buntansha): MINAGAWA Keiji 徳島大学, 大学院ソシオテクノサイエンス研究部, 准教授 (70250959) ; ARAKAWA Yukihiro 徳島大学, 大学院ソシオテクノサイエンス研究部, 助教 (70709203)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: フラビン触媒 / 酸化反応 / 反応場の構築

Outline of Final Research Achievements

We have prepared novel N(5)-unsubstituted neutral flavin catalysts bearing effective reaction site as highly active and practical organocatalysts. These include (1) supramolecular flavin gel catalysts by self-assembly of flavin-containing low-molecular-weight gelators, (2) layered double hydroxide-supported flavin catalysts by intercalation of hydrotalcite by flavin carboxylic acid derivatives, and (3) polymer-supported flavin catalysts by co-polymerization of flavin-containing monomers such as flavin-containing styrene and flavin-containing methacrylate. These novel catalysts did not catalyze oxygenation of sulfides; however, they exihibit high catalytic activity towards aerobic hydrogenation reactions due to the reaction site introduced around the flavin molecules.

Free Research Field

有機合成化学