Development of high- pressure medical gas preservation of lung

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670608
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kagawa University
• Principal Investigator: Yokomise Hiroyasu 香川大学, 医学部, 教授 (80231728)
• Co-Investigator(Kenkyū-buntansha): GO TETSUHIKO 香川大学, 医学部付属病院, 講師 (50313656) ; OKUDA MASAYA 香川大学, 医学部付属病院, 助教 (60448355) ; NAITOU MUNEKAZU 愛知医科大学, 医学部, 教授 (10384984)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺保存 / 高圧ガス / 肺移植

Outline of Final Research Achievements

We successfully established the canine lung transplantation model. We made the chamber which can preserve a lung in the high-pressure carbon monoxide(CO) and oxygen(O2)-mixed gas (PCO=4,000hPa+PO2=3,000hPa). Donor lungs were flushed with ET-KYOTO solution, then stored at 4℃ for 20 hours by the condition of PCO=4,000hPa+PO2=3,000hPa. The stored lungs were transplanted and confirmed to function. It's the completely new organ preservation method. There is a possibility to preserve a lung for long hours safely.

Free Research Field

呼吸器外科