2014 Fiscal Year Final Research Report
The development of new hydrazine organocatalysts and their application
| Project/Area Number |
25810022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 不斉有機触媒 / フッ素化反応 |
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| Outline of Final Research Achievements |
This research mainly focused on the development of new hydrazine organocatalysts designed for multisubstituted aldehydes. First, we planned the synthesis of desired hydrazine organocatalysts, however the original design of the target compound was revealed unstable, and required for redesigning the structure. Additionally, the selection of substituted aldehydes was investigated for direct fluorination with new and reported organocatalysts. Among four structurally different unsaturated aldehydes, two showed promising results for highly stereoselective and enantioselective reactions, which can apply for the synthesis of now building blocks for fluorinated bioactive compounds.
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| Free Research Field |
有機合成
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