2014 Fiscal Year Final Research Report
Regulation of cytoplasmic HDACs relating HSP90 protein
| Project/Area Number |
25860965
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
|
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| Research Institution | Iwate Medical University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 皮膚腫瘍学 / HSP90 / CYLD / ERBB2 / HSF1 |
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| Outline of Final Research Achievements |
Heat shock protein 90 (HSP90) is a unique shaperon protein which ERBB2, AKT, RAF, BCR-ABL and mutant p53 proteins are client proteins controlling their conformational change. The present study could not demonstrated the direct interaction between nucleus accumbens-associated protein 1 (NACC1) and deubiquitinase, cylindromatosis (CYLD) resulting in downregulation HSP90 functions.
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| Free Research Field |
皮膚科学
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