Photodynamic diagnosis mediated 5-ALA for peritoneal metastasis due to advanced gastric cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: TAKAHASHI Tuyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (50452389)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 5-ALA / PDD / photodynamic diagnosis / 5-aminolevulinic acid

Outline of Final Research Achievements

In advanced gastric cancer, the diagnosis of peritoneal metastasis is mandatory prior to the decision of therapy. Photodynamic diagnosis (PDD) by 5-aminolevulinic acid (ALA) has been proposed for peritoneal metastasis in staging laparoscopy and showed higher sensitivity than that of conventional examination. The aim of this study was to evaluate the effectiveness and safety of ALA-PDD for the diagnosis of the peritoneal disseminations. Fifteen advanced gastric cancer patients who had the signs of peritoneal metastasis pointed out by CT scan were included. We evaluate the additional detection rate compared to the conventional examination and safety. The additional detection rate was 6.7 %( 1/15) and the incidence of adverse effect was 13.4 %( nausea, Grade 1). The ALA-PDD was effective and safe examination for the peritoneal metastasis of gastric cancer. And, we are now going to conduct the new investigator initiated trial.

Free Research Field

消化器外科