2017 Fiscal Year Final Research Report
Gene expression analysis in articular cartilage degeneration focused on the role of transcriptional factor C / EBP beta
| Project/Area Number |
25861328
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 軟骨代謝 / 転写因子 / 靭帯骨化 |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the role of C/EBP beta in a joint cartilage degenerative disease. In the previous study, we elucidated that C/EBP beta regulates the expression of cartilage degradative enzyme in vivo and vitro. We hypothesized that C/EBP beta plays a central role in the process of cartilage metabolism, especially in that of degradation. In this study, we examine that C/EBP beta mediates the interaction with the other transcriptional factors and suppresses the catabolic factors resulting in cartilage degeneration. The result obtained was not what we were hypothesized as mentioned above. The problem of this study is considered that the gene transportation to the chondrocyte is technically difficult. We converted an experimental design to the ossification process of the chondrocyte. We already have presented the result of this study at an academic conference and are planning to publish a paper to the scholarly article.
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| Free Research Field |
軟骨代謝
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