2015 Fiscal Year Final Research Report
Role of Staphylococcus aureus alpha-toxin and IL-22 in the pathogenesis of eosinophilic rhinosinusitis
| Project/Area Number |
25861562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | IL-22 / 好酸球 / MUC１ / 副鼻腔炎 / 鼻茸 / アスピリ不耐 / 黄色ブドウ球菌 / 気道炎症 |
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| Outline of Final Research Achievements |
98.8% of Staphylococcus aureus detected in middle meatus of patients with chronic rhinosinusitis showed alpha-hemolysis, suggesting a high presence of alpha-toxin in the nose. Nasal polyp cells produced substantial amounts of IL-5, IL-13, IFN-gamma, IL-10 and IL-17A in response to alpha-toxin in ICAM-1 dependent manner. In addition, the polyp cells produced IL-22 in response to the toxin. Impairment of alpha-toxin-induced IL-10 production was associated with eosinophilic inflammation and lower airway obstruction. Furthermore, IL-22 induced MUC1 expression by nasal epithelial cells which was dependent on IL-22 receptor expression.
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| Free Research Field |
耳鼻咽喉科学、臨床微生物学、アレルギー学
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