2014 Fiscal Year Final Research Report
Functional analysis of Alarmin receptors in the pathogenesis of pulpitis
| Project/Area Number |
25861803
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HIRAO Kouji 徳島大学, 大学病院, 助教 (00581399)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 歯髄炎 / 象牙芽細胞 / alarmin / MINCLE |
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| Outline of Final Research Achievements |
Alarmins, endogenous immunofactors secreted to necrosis are an important factor that becoming serious of sepsis, it hypothesized to have an important role to rapid progression of pulp necrosis in pulpitis. In this study, I focused on alarmin and its receptor, analyzed for alarmin role and function in pulpitis.
As the result, Mincle which is one of the alarmin receptor is expressed in rat odontblastic cells (KN-3) and, its expression is increased by stimulation with Pathogen-associated molecular patterns. Moreover, I demonstrated that CCL4 mRNA expression is up-regulated by the stimulation with TDM which is MINCLE rigand.
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| Free Research Field |
歯科保存学
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