2016 Fiscal Year Final Research Report
A new application of photodynamic therapy for oral cancer
| Project/Area Number |
25861979
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University (2013-2014, 2016)
Kyorin University (2015) |
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Principal Investigator |
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| Research Collaborator |
ENOKI Shigenori 株式会社LSIメディエンス
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 局所進行口腔癌 / 組織穿刺型プローブ / 組織内PDT |
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| Outline of Final Research Achievements |
Photodynamic therapy is currently used to treat early stage oral cancer. Expanding its application to locally advanced oral cancer may benefit patients. This study investigated the therapeutic effect of intra-tissue photodynamic therapy (interstitial PDT: iPDT) using a prototype tissue puncture probe. A system was established that connected all-around irradiation type probes used for a conventional "PD laser" and that performed iPDT. The antitumor effect of this system was investigated in nude mice that received transplants of human oral tumors. The relative tumor volume differed significantly in the iPDT-treated and non-irradiated groups. These findings suggested that this system might provide antitumor effects.
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| Free Research Field |
外科系歯学
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