Search for new biomarker of anti-cancer drug effect using near-infrared diffuse optical spectroscopy targeting vasculature and hypoxia

2017 Fiscal Year Final Research Report

• Project/Area Number: 26282144
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SAKAHARA Harumi 浜松医科大学, 医学部, 教授 (10187031)
• Co-Investigator(Kenkyū-buntansha): 芳澤 暢子 浜松医科大学, 医学部附属病院, 助教 (10402314) ; 上田 重人 埼玉医科大学, 医学部, 助教 (20646947) ; 佐伯 俊昭 埼玉医科大学, 医学部, 教授 (50201512) ; 小倉 廣之 浜松医科大学, 医学部, 助教 (50402285) ; 久慈 一英 埼玉医科大学, 医学部, 教授 (90283142)
• Co-Investigator(Renkei-kenkyūsha): YAMASHITA Yutaka 浜松ホトニクス株式会社, 中央研究所, 研究主幹(理事) (80393982) ; UEDA Yukio 浜松ホトニクス株式会社, 中央研究所・第7研究室, 副研究室長 (30393987)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 画像診断システム / 拡散光イメージング / 乳がん

Outline of Final Research Achievements

Diffuse optical spectroscopy is used for evaluation of tumor blood volume quantified by tissue hemoglobin concentrations. We investigated whether early changes in tumor total hemoglobin concentration predict a pathological complete response (pCR) to neoadjuvant chemotherapy in patients with operable breast cancer, and we compared the predictive value of pCR between optical spectroscopy and FDG-PET. Although changes in tumor hemoglobin concentration predicted pCR to chemotherapy with moderate accuracy, the diagnostic performance of optical spectroscopy was not superior to that of metabolic response monitored by FDG-PET.

Free Research Field

核医学、放射線診断学