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2017 Fiscal Year Final Research Report

Interaction between the higher-order motor areas and the basal ganglia in associating cognition and action

Research Project

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Project/Area Number 26290012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

HOSHI Eiji  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (50407681)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords前頭葉 / 大脳基底核 / 行動決定 / 動作選
Outline of Final Research Achievements

In the process of choosing and executing behavior it is suggested that the multiple areas in the frontal cortex and the basal ganglia play a crucial role. However, the underlying neural mechanisms in terms of functions and networks remain elusive. In the analysis of functions, we found a functional gradient within the frontal cortex. We also found that in making decisions the frontal cortex plays a primary role, while the basal ganglia are mainly involved in retrieving a decision made by other areas, such as the frontal cortex. Further, by comparing neurons in a cortical motor area and the thalamic reticular nucleus, a gateway in the cortico-basal ganglia network, and we found that this nucleus plays a role as an activity filter. In the analysis of networks, we found that a cortical area receives diverse inputs from multiple territories of the basal ganglia. Altogether, these results further revered functional and structural mechanisms underlying behavioral control.

Free Research Field

神経科学

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Published: 2019-03-29  

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