Evaluation of causa association between diabetes and cancer by Mendelian randomization analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26290046
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Tsugane Shoichiro 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 社会と健康研究センター長 (40179982)
• Co-Investigator(Kenkyū-buntansha): 岩崎 基 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 部長 (60392338) ; 後藤 温 東京女子医科大学, 医学部, 助教 (80644822)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 疫学研究 / がんの危険因子 / 糖尿病 / 予防医学

Outline of Final Research Achievements

We conducted a Mendelian randomization (MR) analysis among approximately 3,750 incident cancer cases and 13,000 subcohort participants in the Japan Public Health Center-based Prospective Study (JPHC Study) to investigate an association between diabetes mellitus and cancer incidence. Using 29 single nucleotide polymorphisms as instrumental variables, the MR analysis indicated no association between diabetes and cancer. In site-specific analyses, no associations were found for pancreatic, liver, or colorectal cancer. Our findings suggest that diabetes per se may not be a true risk factor for cancer.

Free Research Field

疫学