2016 Fiscal Year Final Research Report
Molecular mechanism of mitochondrial autophagy
| Project/Area Number |
26291039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Shun-ichi 新潟大学, 医歯学総合研究科, 助教 (30529095)
SAIGUSA Tetsu 新潟大学, 医歯学総合研究科, 研究員 (50421954)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミトコンドリア / オートファジー |
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| Outline of Final Research Achievements |
We have studied the molecular mechanism of mitochondria autophagy or mitophagy in yeast and mammalian cells. We found that two MAP kinases, Erk2 and p38, are required for mitophagy in mammalian cells. We also found that the Sin3-Rpd3 complex suppresses the expression of mitophagy essential factor Atg32 under the regulation of Tor in yeast. In addition, we found that when isolation membrane enwraps mitochondria, it contributes to divide mitochondria to the suitable size for enwrapping during mitophagy.
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| Free Research Field |
細胞生物学
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