2017 Fiscal Year Final Research Report
Molecular mechanisms underlying heterochromatin assembly
| Project/Area Number |
26291072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | National Institute for Basic Biology (2016-2017)
Nagoya City University (2014-2015) |
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Principal Investigator |
Nakayama Jun-ichi 基礎生物学研究所, クロマチン制御研究部門, 教授 (60373338)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 遺伝子 / 発現制御 / ヘテロクロマチン / 分裂酵母 / ユビキチン化 |
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| Outline of Final Research Achievements |
In this study, we focused on Clr4 methyltransferase complex (CLRC), and investigated a functional link between ubiquitin modifications and heterochromatin assembly. Affinity purified CLRC was shown to ubiquitylate histone H3. We further demonstrated that H3 ubiquitylation was tightly associated with H3K9me-enriched chromatin and that H3 ubiquitylation promotes H3K9 methylation by Clr4.
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| Free Research Field |
分子生物学
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