Basic study on HIV-1 replication and pathogenicity in host individuals: functional analysis of accessory proteins

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293104
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: The University of Tokushima
• Principal Investigator: ADACHI Akio 徳島大学, 大学院医歯薬学研究部, 特命教授 (90127043)
• Co-Investigator(Kenkyū-buntansha): 野間口 雅子 徳島大学, 大学院医歯薬学研究部, 准教授 (80452647) ; 宮崎 恭行 徳島大学, 大学院医歯薬学研究部, 助教 (70607233)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ウイルス / HIV-1 / HIV-1rmt / アクセサリー蛋白質 / アカゲザル

Outline of Final Research Achievements

It is critically important to establish the rhesus/viral infection system to elucidate HIV-1 replication and pathogenicity in host individuals. We have made every effort to generate CCR5- and rhesus macaque-tropic HIV-1 (HIV-1rmt) clones that grow enough to cause persistent infection and finally induce AIDS. We have successfully obtained molecular HIV-1rmt clones that grow equally or better in rhesus cells relative to the best-growing CXCR4-tropic HIV-1rmt previously described. We thus have advanced to the rhesus-infection experiments to functionally analyze HIV-1 accessory proteins.

Free Research Field

ウイルス学