Collection and survey of biosynthetic genes of spore-derived biologically active substances and clarification of biosynthetic machinery

2017 Fiscal Year Final Research Report

• Project/Area Number: 26303005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Biomolecular chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Abe Ikuro 東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)
• Co-Investigator(Kenkyū-buntansha): 脇本 敏幸 北海道大学, 薬学研究院, 教授 (70363900)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 海洋天然物 / 生合成遺伝子 / 海綿動物 / 共生菌

Outline of Final Research Achievements

By collecting sponges in the Pacific region and isolating and comparing biosynthesis genes, we elucidated its biosynthetic machinery and searched for origin of structural diversity of natural products. At the same time, we investigated the possibility of producing bacteria common to these sponges and investigated the universality of the distribution of symbiotic bacteria excelling in substance production. As a result, the importance of marine biological resources in the Pacific region was demonstrated, and great contribution was expected to future drug development.

Free Research Field

生物分子科学