The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Josai University
• Principal Investigator: Keizo Kasono 城西大学, 薬学部, 教授 (90177387)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病 / 糖尿病合併症 / n-3系多価不飽和脂肪酸 / エイコサペンタエン酸 / 血管内皮機能 / 脂肪酸

Outline of Final Research Achievements

<1> The administration of palmitoleic acid (POA) for 2 weeks improved the insulin resistance and reduced the plasma glucose levels in diabetic model mice (KKA-y). It was speculated that the administration of POA compensatory increased the relaxation response induced by PPAR-δ.<2> Eicosapentaenoic acid (EPA) dose-dependently decreased the up-regulated protein levels of VCAM-1 and ICAM-1 induced by TNF-α in human aortic endothelial cells.<3> It is speculated that fish oil supplementation reduces the cardiovascular loading induced by increase of Ht during hypoxic training without blunting the improvement of endurance performance.

Free Research Field

生活習慣病