Research in the regulation of feeding behavior - the role of central dopamine neurons -

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Hoshi University
• Principal Investigator: IKEDA Hiroko 星薬科大学, 薬学部, 准教授 (70297844)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 摂食調節 / ドパミン神経 / ドパミン受容体 / 視床下部

Outline of Final Research Achievements

The present study examined the role of dopaminergic functions in the lateral hypothalamus (LH) in the regulation of feeding behavior. The results in the present study have indicated that dopamine neurons in the LH are activated by food intake, which inhibits food intake by activating dopamine D1 and D2 receptors. In addition, it is suggested that dopamine D1 and D2 receptors in the LH have an inhibitory role in the regulation of feeding behavior through agouti-related peptide (AgRP) / neuropeptide Y (NPY) neurons and orexin neurons, respectively.

Free Research Field

神経科学