2017 Fiscal Year Final Research Report
Clarification of the role of magnesium homeostasis in colorectal cancer
| Project/Area Number |
26430113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 大腸がん / マグネシウム / カルシウムチャネル / 腸管上皮細胞 |
|---|
| Outline of Final Research Achievements |
The Mg2+ transporter CNNM4 maintains cellular magnesium homeostasis through its Mg2+ extrusion activity, and intracellular Mg2+ levels are significantly increased in Cnnm4-deficient cells. An analysis using mouse models of colorectal cancers shows that depletion of Cnnm4 promotes tumorigenesis and tumor progression in intestinal tissues. These results suggest that CNNM4 suppresses intestinal tumor development through regulation of the level of intracellular magnesium.
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| Free Research Field |
疾患生物学
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