Degeneration- and regeneration-inducing mechanism in neuronal axon

2017 Fiscal Year Final Research Report

• Project/Area Number: 26440008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Molecular biology
• Research Institution: Wakayama Medical University
• Principal Investigator: Hirai Syu-ichi 和歌山県立医科大学, 医学部, 教授 (80228759)
• Co-Investigator(Renkei-kenkyūsha): YAMASAKI Hisashi 和歌山県立医科大学, 医学部, 准教授 (20212285)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 軸索 / 微小管 / シグナル伝達 / 大脳皮質

Outline of Final Research Achievements

We investigated axon regeneration as well as axon formation in developing neurons, from a point of view of the function of a gene that we have identified as a key molecule for the development of mouse cerebrum. The results indicate that common molecular mechanisms function in the formation and the regeneration of axons, and that such mechanisms are regulated via different signaling pathways. These notions suggest a new approach to promote axon regeneration in damaged central nervous system, that is still challenging.

Free Research Field

分子生物学