2016 Fiscal Year Final Research Report
Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte
| Project/Area Number |
26461133
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
Miura Tetsuji 札幌医科大学, 医学部, 教授 (90199951)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | mitochondria / cell death / necroptosis / autophagy / signal transduction |
|---|
| Outline of Final Research Achievements |
This study showed that, in contrast to its role in necrosis, mitochondrial permeability transition (MPT) does not directly trigger cell death in necroptosis of cardiomyocytes and that necroptotic signals significantly inhibit autophagy, which is potentially modulated by MPT, leading to exaggeration of necroptotic cardiomyocyte death. Sequestration of p62 from p62-LC3-II interaction by increased p62-RIP1 interaction and inhibition of fusion of autophagosomes with lysosomes were proposed to be mechanisms by which necroptotic signals inhibits autophagy.
|
| Free Research Field |
循環器病学
|
