• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

(Pro)renin receptor-mediated pathophysiology in crescentic nephritis

Research Project

  • PDF
Project/Area Number 26461612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

URUSHIHARA Maki  徳島大学, 病院, 講師 (50403689)

Research Collaborator NAGAI Takashi  
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsアンジオテンシン / 半月体形成性腎炎 / レニン
Outline of Final Research Achievements

To examine whether direct renin inhibition ameliorate renal injury in crescentic glomerulonephritis, we investigated the effects on renal injury in experimental animal model. As a result, glomerular crescents rates and proteinuria were reduced by the treatment with direct renin inhibitor. Furthermore, primary cultured glomerular cells indicated cell proliferation and macrophage infiltration via (pro)renin receptor. These results suggest that therapeutic strategy of direct renin inhibition may prove beneficial for crescent GN and the novel mechanism via (pro)renin receptor are involved in glomerular crescent formation.

Free Research Field

内科系臨床医学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi