Comprehensive evaluation with 320-row MDCT for coronary artery stenosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461780
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Oyama-Manabe Noriko 北海道大学, 大学病院, 講師 (70463742)
• Co-Investigator(Renkei-kenkyūsha): Kikuchi Yasuka 北海道大学, 医学(系)研究科(研究院), 特任助教 (80783539)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心筋血流 / 心筋虚血 / 冠動脈 / コンピューター断層撮影 / 機能的狭窄度

Outline of Final Research Achievements

By using low-dose dynamic CTP with 320-row multi-detector CT (MDCT), we have developed a comprehensive method to estimate myocardial blood flow derived from CT (MBFCT) and coronary flow reserve derived from CT (CFRCT), validated with 15O-water PET. We also hypothesized that the severity of CAD might inversely correlate with the MBFCT and CFRCT. Quantitative per-patient and per-vessel CFRCT and hyperemic MBFCT assessed with 320-row MDCT, showed a moderately good diagnostic performance for identifying patients with obstructive CAD in a clinical setting. CFRCT and MBFCT are clinically useful for evaluating CAD and may contribute to pathophysiological investigations of CAD.

Free Research Field

放射線医学