Development of CEST-based molecular MR imaging for brain tumors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461827
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TOGAO Osamu 九州大学, 大学病院, 助教 (10452749)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: MRI / 脳腫瘍 / 神経膠腫 / CESTイメージング / APTイメージング

Outline of Final Research Achievements

Toward the clinical application of amide proton transfer (APT) imaging of brain tumors, we developed and optimized APT MR imaging sequences on a clinical MR scanner. We developed the parallel transmission based APT imaging and 3D fast spin echo Dixon method. With this sequence, we evaluated the effect of saturation pulse length on the APT contrast of brain tumors and found that APT contrast of glioma was increased with the length of saturation pulse. APT signal was increased with WHO grade of glioma. APT imaging showed better diagnostic performance in differentiating high-grade from low-grade gliomas compared to contrast enhanced imaging, diffusion-weighted imaging, and perfusion weighted imaging. APT imaging could be a non-invasive clinical tool for assessing brain tumors.

Free Research Field

神経放射線科学