Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Keio University
• Principal Investigator: Ohtsuka Takashi 慶應義塾大学, 医学部(信濃町), 准教授 (40306717)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺移植 / 拒絶反応 / メタロプロテアーゼ

Outline of Final Research Achievements

Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). We investigated inhibitor of Matrix metalloproteinases (MMPs) could ameliorate acute rejection in mouse trachea transplantation model. MMP inhibitor was given to the transplanted mice. The acute rejection of tracheal transplant was decreased in the allograft treated with MMP inhibitor. Regulatory T-cell infiltration and IL-10 mRNA expression increased in the allograft treated with MMP inhibitor. MMP inhibitor could be the treatment option for BO after lung transplantation.

Free Research Field

呼吸器外科学