Development of combination theray with hyperthermia and Interleukin-1 inhibitor.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Yokohama City University
• Principal Investigator: SENRI Oguri 横浜市立大学, 医学部, 助教 (30400394)
• Co-Investigator(Kenkyū-buntansha): 中島 英行 横浜市立大学, 医学研究科, 客員研究員 (30437032) ; 來生 知 横浜市立大学, 医学部, 准教授 (30545059) ; 光藤 健司 横浜市立大学, 医学部, 准教授 (70303641)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 進行口腔癌 / IL-1R / 温熱療法 / 併用療法

Outline of Final Research Achievements

To develop new therapies that are highly efficient and safe for advanced oral cancer, we have started studing of hyperthermia treatment combined with targeted therapy using Interleukin-1（IL-1）inhibitor. We have expected to the synergestic efficacy for modulating the expression of targeting molecule by hyperthermia.
In our results, the expression level of IL-1R was increased after hyperthermia in OSC-19 cells, which is one of the oral squamous cell carcinoma cell line, by western blotting. Moreover, cell motility assay showed that the group of which treated with combination therapy with both IL-1Ra (IL-1 inhibitor) and hyperthermia in OSC-19 cells, significantly reduced the cell motility compared to other groups.

Free Research Field

口腔外科